Saturday, 14 November 2015

Estrogen and Progesterone Receptors Expression in Resected Gallbladder from Gall bladder Carcinoma Cases

Abstract Gallbladder carcinoma is most common malignancy of gartrointestinal tract (GIT) with poor diagnosis. Its prevalence is higher in females that too of northern India. This study aimed to identify the role of sex hormones in carcinoma gallbladder (CA GB). Resected 100 gall bladders of CA GB were examined immune-histo-chemicaly to find out ER and PR status with its association with its underlying histopathology. It was found in this study that PR status was observed in 36% of cases whereas ER status was positive in 2% of CA GB cases. It was also revealed that ER expression was specific and PR expression was more sensitive indicator in differentiating between benign and malignant carcinoma gall bladder.

Keywords Gall Bladder Carcinoma, ER Status, PR Status

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